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The ozone layer is a natural layer of gas in the stratosphere layer that protects humans and other living things from harmful ultraviolet (UV) radiation from the sun. Chlorofluorocarbons or CFCs are the main cause of Ozone layer depletion that includes chlorofluorocarbon, carbon tetrachloride, hydrochlorofluorocarbons, methyl chloroform and halons. These are released by solvents, spray aerosols, refrigerators, air-conditioners, Fire-extinguishers and dry-cleaning agents etc. Ozone layer is naturally depending on temperature, weather, altitude and volcanic eruptions. The depletion of the ozone layer has harmful effects on the environment. The humans will be directly exposed to the harmful ultraviolet radiations of the sun may result in serious health issues such as skin diseases, cancer, sunburns, cataract and weak immune system. Strong UV rays lead to minimal growth, flowering and photosynthesis in plants. Planktons are greatly affected and If the planktons are destroyed, the organisms present in the aquatic food chain are also affected.